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Cyspera® is an intensive pigment corrector formulated with stabilized cysteamine to improve the appearance of stubborn skin discoloration, brown patches and dark spots.

Cyspera® is a professional skin care product that can be purchased through a physician. To find a distributor, please visit our website www.cyspera.com.

Cysteamine contained in Cyspera® (the only cream with stabilized cysteamine) is a synthesized molecule that delivers powerful antioxidant activity in the skin with multiple effects on the appearance of hyperpigmentation.

Cyspera® is recommended for skin discoloration related to sun exposure, and/or brown patches, dark spots, lentigos...

Cyspera® can be used on all Fitzpatrick skin types.

Cyspera® best performance has been demonstrated when it's used regularly (15 minutes once per day)
Intensive phase: Once per day for 16 weeks
Maintenance phase: Twice-weekly, once per day

1. Apply a thin layer on the skin
2. Leave on for 15 minutes.
3. Remove by washing the area with a mild facial cleanser. Gently pat your face dry.
4. Moisturize the area. Maintain skin hydration during the day.

The daily use of a broad spectrum sunscreen with SPF 50 is highly recommended.

Cyspera® can be used for long periods of time. Based on clinical setting observations, improvement continues to be seen after 16 weeks and cysteamine has been prescribed for 6 months of daily use with positive results.
Once the desired results are achieved, they can be maintained with twice weekly applications of topical Cyspera®.
Some of the first Cyspera® patients are still under maintenance regimen.

Cysteamine is not a photosensitiser. Cyspera® can be applied regardless of the sun intensity. However the daily use of a high SPF sunscreen cream is recommended to achieve results more rapidly.

We recommend to apply Cyspera® on the entire face and not just on the pigmented areas. It will uniform the overall skin tone and act in depth on the darkest areas.

Cyspera® is safe to be used on any part of the body (under the eye, lips, bikini lines, arms, inner thigh…)
For sensitive areas, we recommend to dilute Cyspera® with your moisturizing cream and leave on for 5 minutes for the first days. If no irritation is observed, you can gradually increase the exposure time up to 15 min maximum.

Cyspera® best performance has been demonstrated when applied for 15 minutes everyday. Longer application time may increase skin sensitivity, especially in the initial stages

A longer exposure to the cream will not provide quicker results. Cyspera® best performance has been demonstrated when applied for 15 minutes everyday. A constant treatment for 3 up to 6 months will give you the best results.

In clinical studies, results were seen as early as 8 weeks with daily use. After 16 weeks of usage, significant improvement in the appearance of skin discoloration has been observed.

Any moisturizing cream can be applied.
The daily use of a broad spectrum sunscreen with SPF 50 is highly recommended.

Applying Cyspera® to wet or damp skin may result in increased skin sensitivity.

We have not studied the tolerability of Cyspera® and hydroquinone used in combination. This should be left to the discretion of the physician based upon their knowledge of the patient’s skin needs and tolerability.

We have not studied the tolerability of Cyspera® and retinols used in combination. This should be left to the discretion of the physician based upon their knowledge of the patient’s skin needs and tolerability.

We have not studied the tolerability of Cyspera® and retinols used in combination. This should be left to the discretion of the physician based upon their knowledge of the patient’s skin needs and tolerability.

Cyspera® can be used in combination with cosmetic procedures. The timing of pre- and post-procedure usage should be left to the physician’s discretion based upon their knowledge of the patient’s skin needs and tolerability.

Cyspera® can be used before or after any laser treatment. The skin must be completely rested without any apparent irritation. After the laser treatment, it is recommended to wait for 15 days before starting Cyspera®. Any combination treatment should be left to the physician’s discretion.

Cyspera® can be used in conjunction with chemical peels. The skin must be completely rested without any apparent irritation. After a chemical peel treatment, it is recommended to wait for 15 days before starting the Cyspera® regimen. Any combination treatment should be left to the physician’s discretion.

No study for use in pregnant and breastfeeding mothers has been conducted. Therefore, we recommend not to use Cyspera® during pregnancy and breastfeeding.

No significant side effects, other than redness, dryness or irritation of the skin have been reported. The risk of irritation is very low if the mode of application is respected.

This is a normal reaction that may happen during the first few days of treatment.
In case of sustained redness, we recommend to stop using Cyspera® for a few days (or until skin redness is completely subsided) and continue to moisturize the skin frequently. When the skin redness is completely subsided, re-start the application of Cyspera® cream with lower exposure times (5 to 10 minutes only) and/or frequency of applications (once every other day). The exposure time can be gradually increased to 15 minutes over a few weeks if there is no sign of redness.

Dryness of the skin may occur in the first few days of application, while the skin is adjusting. The frequent use of a moisturizer is very important as skin dryness can increase irritation. In case of sustained dryness, we recommend to stop using Cyspera® for a few days (or until skin dryness is completely subsided) and continue to moisturize the skin frequently. When the skin dryness is completely subsided, re-start the application of Cyspera® cream with lower exposure times (5 to 10 minutes only) and/or frequency of applications (once every other day). The exposure time can be gradually increased to 15 minutes over a few weeks if there is no sign of dryness.

Cysteamine is naturally present in the human body at a high concentration.

Cyspera® has not been tested to determine acnegenic or comedogenic potential.

Vitiligo is an unpredictable condition, which pathophysiology is not well characterised in the scientific literature. Although multiple hypotheses have been suggested as potential triggers that cause vitiligo, studies strongly imply that changes in the immune system are responsible for the condition by attacking and destroying the melanocytes of the skin. Tyrosinase, which is not a component of the immune system but is an enzyme involved in melanogenesis activation in melanocytes, plays as a major autoantigen in generalized vitiligo. Some believes that hyperpigmentation through the hyperactivity of Tyrosinase (or rather its hyper-concentration) can cause or exacerbate vitiligo. No interaction have been characterised between cysteamine and vitiligo. Incidentally, by down-regulating the activity of tyrosinase, cysteamine may even, in principle, reduce the risks of vitiligo.

Hyperpigmentation may result from subclinical irritation that causes the skin to get darker. We recommend stopping using Cyspera® for 2 weeks and moisturize several times daily. Re-start the application of Cyspera® cream with lower exposure times (5 to 10 minutes only) and/or frequency of applications (once every other day). The exposure time can be gradually increased to 15 minutes over a few weeks if there is no sign of redness.

The efficacy of topical cysteamine is linked to the chronicity and compliance of the treatment over a period of time, rather than the daily duration of exposure. In some patients underlying skin inflammation, sun exposure etc. are impacting response rate negatively, and longer treatment duration might be necessary to achieve the optimal results.