The product
- Cyspera^® Cysteamine
- Where to buy
  - - - Where to buy Cyspera^®
        
        Cyspera^® Intensive Pigment Corrector is only available through dispensing clinics. You can place your order by searching the nearest clinic to your location.
        
        Where to buy
- How to use
  - - - Short-contact application
        Intensive phase: Once per day, everyday, for 16 weeks.
        Maintenance phase: Once per day, twice-weekly.
        
        How to use
- Before & After
  - - - Before & After results
        
        The clinical cases listed below are hyperpigmentation cases treated by certified dermatologists and healthcare professionals.
        
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- FAQ
  - - - Frequently asked questions
        
        Ask us anything
Pigmentation concerns
- MelasmaMelasma: A Cosmetic Concern The skin is the largest organ of human body. While it has many physiological functions, it also gives a beautiful outlook. Everyone wishes to have an even-toned and flawless skin, and strives for it. However, some conditions can involve the skin, and affect its beauty. One of these conditions is melasma. Melasma is a skin problem that leads to dark discoloration of the skin in a patchy pattern. It is also commonly referred as hyperpigmentation. It is more common among women, and usually affects young women. Pregnant females can also experience melasma during pregnancy due to hormonal changes. It is also called “mask of pregnancy” for the same reason. How to Identify Melasma? It is difficult to differentiate between melasma and post-inflammatory hyperpigmentation (PIH) sometimes. Melasma appears darker than the normal skin tone and is brownish in color. It affects both sides of your face in a similar fashion that can help identifying this condition. It affects forehead, cheeks, nose, chin and lips. Also, other sun-exposed areas like forearms and neck can be involved. What is the Cause of Melasma? There are different factors that can play their roles in causing skin discoloration. One or more…
  - - - Melasma: A Cosmetic Concern
        
        The richness of the diverse human experience is reflected in the wide array of skin tones found around the world. Melanin is the pigment that gives color to the skin and helps to protect it from sun damage. The darkening of the skin that occurs after exposure to the sun is actually part of the skin’s natural process of protection from sun damage. Hormonal changes can also lead to increased melanin production and changes in skin tone...Read more
- Post-inflammatory hyperpigmentationPost-inflammatory Skin Hyperpigmentation What is inflammation? Our body undergoes something called ‘inflammation’ when it is attacked by harmful agents like microbes, toxins or diseases. The body fights back and protects itself with an army of white blood cells, antibodies and various chemicals (e.g. cytokines and interferons. Externally, the body part that undergoes inflammation may appear: Red Heated (have raised temperature) Painful/tender to touch Swollen However, in the end, when our body finally wins, the battle wounds may still remain. What is Post-Inflammatory Hyperpigmentation? Post-inflammatory hyperpigmentation is the aftermath of inflammation. The skin that is involved may turn purple, brown or tan – and may or may not be tinted with grey or blue hues – which makes the skin look darker or ‘more pigmented’. In medical jargon, this is termed as hyperpigmentation (more color). These hyper-pigmented areas present as flat spots on the skin surface. Naturally, skin that is already pigmented would look more pigmented quickly. Hence, this skin condition is very common among people of color, e.g. African Americans. What Causes Post-Inflammatory Hyperpigmentation? Skin is formed by various cells, arranged in many layers one above the other. Skin cells try to protect themselves from inflammation by inducing melanocytes (pigment…
  - - - Post-Inflammatory Hyperpigmentation (PIH): A Lingering Skin Concern
        
        Inflammation can occur in any part of the body, including in the skin. The visible signs of inflammation—swelling and redness—develop as a result of the body’s natural defense against microbes, toxins, diseases, etc. When the body detects insult, white blood cells, antibodies, and various other inflammatory mediators, including cytokines and interferons, flood the affected area...Read more
- Periorbital hyperpigmentationWhat is hyperpigmentation? Hyperpigmentation of the skin occurs when a portion of skin is darker than other surrounding areas of skin. This occurs due to melanin. Melanin is the protein that is secreted by skin cells. Melanin gives skin its color. When the skin produces more melanin, it leads to hyperpigmentation. What is periorbital hyperpigmentation? Peri means ‘around’ and hyperpigmentation means ‘darkness’, so periorbital hyperpigmentation is darkness around the orbit (the place our eyeballs are seated in), or plainly “dark circles”. Periorbital hyperpigmentation (POH) is also known as periocular hyperpigmentation, periorbital melanosis, dark circles, infraorbital darkening, infraorbital discoloration, or idiopathic cutaneous hyperchromia of the orbital region. What are the types of periorbital hyperpigmentation? Periorbital hyperpigmentation is divided into 4 types on the basis of clinical pattern of pigmentation, namely: Pigmented (brown color) Vascular (blue/pink/purple color) Structural (skin color) Mixed type pigmented-vascular (PV) pigmented-structural (PS) vascular-structural (VS) Combination of PV, PS and VS types What does periorbital hyperpigmentation look like? Periorbital hyperpigmentation presents as bilateral round or semicircular homogenous brown or dark brown pigmented macules in the periocular region. In simple terms, they look like dark circles around the eyes. What are the causes of periorbital hyperpigmentation (POH)? Periorbital hyperpigmentation can be…
  - - - What is Perioral or Periorbital Hyperpigmentation?
        
        Hyperpigmentation is a condition where a portion of skin appears darker than other surrounding areas of skin due to excess melanin in the affected areas. Melanin is the pigment that gives color to the skin. Sometimes hyperpigmentation can appear around the mouth (perioral) and eyes (periorbital). “Peri” is a prefix from Greek meaning “around” or “surrounding”; oral relates to the mouth and orbit refers to the eye...Read more
- Lips hyperpigmentationLips hyperpigmentation Hyperpigmentation of the skin is when a portion of the skin is darker than the other surrounding areas. This occurs due to melanin. Melanin is the pigment that is produced by cells called melanocytes. Melanin gives the skin its color. When the skin produces more melanin, it leads to hyperpigmentation. Why are lips differently colored than regular skin? Normally, skin is composed of numerous layers of cells, however, the lips only have 3 to 5 cell layers. This means that skin over lips is thinner. Lips are also richly supplied by blood capillaries. Due to this, lips show the color of blood capillaries beneath them, owing to their crimson or pinkish color. Why are some lips darker than the others? Race: Lips come in a variety of colors and shades. Some people have lips with a more pinkish tone, whereas others have them more in a purplish – or even olive – tone. It all boils down to genetics and race. Those who are fair-complexioned tend to have rosy lips whereas those with darker skin have purplish lips. However, this is not a sure shot rule. Smoking: Cigarettes contain various toxins that can harm your health, leading to…
  - - - Hyperpigmentation on lips
        
        Hyperpigmentation of the skin is when a portion of the skin is darker than the other surrounding areas. This occurs due to melanin. Melanin is the pigment that is produced by cells called melanocytes. Melanin gives the skin its color. When the skin produces more melanin, it leads to hyperpigmentation. Normally, skin is composed of numerous layers of cells, however, the lips only have 3 to 5 cell layers...Read more
- Intimate areasIntimate Areas Hyperpigmentation Hyperpigmentation of the skin is when a portion of the skin is darker than the other surrounding areas. This occurs due to melanin. Melanin is the pigment that is produced by cells called melanocytes. Melanin gives the skin its color. When the skin produces more melanin, it leads to hyperpigmentation. Why do intimate areas get hyperpigmented? Intimate areas are prone to hyperpigmentation. Almost everyone has that problem but it is nothing to be ashamed of. The reason why it is most likely to happen is based on so many factors, some of them being: Friction It is pretty clear that our gentle intimate areas are almost in contact with a surface. Whether you are wearing pants or a skirt, your genitals are subject to friction against either the crotch of your pants or your underwear. This friction is especially bad if you are wearing tight bottoms or the fabric is tough. Constant friction sloughs off cells and as an adaptation, your body produces more and more tougher cells, especially melanocytes, to replace them. This causes the area to darken. Friction can also be caused by shaving. Regular shaving can promote darkening of these areas. Harsh chemicals Harsh…
  - - - Intimate Area Hyperpigmentation: A Common But Personal Concern
        
        Hyperpigmentation or excessive darkening of the skin can appear on any part of the body. It occurs when melanin, the pigment that gives the skin its natural color, collects in the skin in higher than normal amounts. Some forms of hyperpigmentation, such as melasma, have a specific appearance and classification. Other forms of hyperpigmentation are non-specific and may be described based on the area affected...Read more
- Lentigo hyperpigmentationLentigo (Hyperpigmentation) What is lentigo? Lentigo is defined as a small spot on the skin that is pigmented, its edges are clearly defined. This spot is surrounded by normal-appearing skin. It is benign in nature and is due to the overproduction (hyperplasia or increased number) of melanocytes (pigment cells). Owing to their brown-black color, they are also called liver spots. Lentigine is another name for lentigo, contributed by its small, lentil-like appearance. Are Lentigo and freckles the same thing? Not quite. Despite both of them having a hyperplasia of melanocytes, only freckles darken with increased sun exposure. Lentigo remains of the same pigment and does not darken, regardless of sun exposure. What is the difference between Lentigo and Intertrigo? Intertrigo is the hyperpigmentation of skin secondary to a fungal infection. Intertrigo, unlike lentigo, causes itching and foul odor. Does lentigo itch? No, Lentigo does not itch or cause any symptoms. It is merely a darkening of the skin pigment. What are the types of Lentigo? Lentigo (plural: lentigines) is of different types, based on its cause and site of occurrence. Lentigo simplex: It is the most common type and can be seen congenitally on the trunk, arms, and legs. These spots can…
  - - - Lentigo: Uncovering the Facts About “Liver Spots”
        
        Interestingly, the most common form of lentigines, lentigo simplex, is not related to sun exposure. This congenital condition is associated with dark markings on the trunk, arms, and legs. Lentigo simplex may be mistaken for freckles, however, freckles tend to be more numerous and can darken with sun exposure, whereas lentigines do not. Lentigo simplex often disappears with time...Read more
- Body hyperpigmentationAxillae, Elbows and Joints Hyperpigmentation Hyperpigmentation of the skin is when a portion of the skin is darker than the other surrounding areas. This occurs due to melanin. Melanin is the pigment that is produced by cells called melanocytes. Melanin gives the skin its color. When the skin produces more melanin, it leads to hyperpigmentation. Where is hyperpigmentation mostly seen? Hyperpigmentation is mostly seen in either exposed areas, for example skin of the face. However, areas that are closed off and subject to greater amount of friction also experience hyperpigmentation. These areas include the neck, elbows, knees and the axillae (armpits). What causes hyperpigmentation in these areas? Hyperpigmentation seen in closed areas is mostly due to a skin condition called acanthosis nigricans (AN) where patches of velvety texture that are darker than ideal are seen on skin. Other causes of hyperpigmentation of skin include: Accumulated dead skin: The skin needs to be exfoliated to remove the debris and reveal soft, supple skin. UV ray exposure: Ultraviolet rays that may damage the skin if overexposure. A good sunscreen with sufficient SPF is essential. Birth control pills: These magic pills are hormones that prevent from a potential pregnancy. An imbalance of hormones…
  - - - Hyperpigmentation: Understanding Changes in Skin Color
        
        A variety of factors may affect the skin and cause melanocytes to ramp up the production of melanin. In many cases, these reactions are actually part of the skin’s natural defense or healing processes. Consider the darkening of the skin after sun exposure. This darkening or “tanning” is intended to help protect the skin from the damage caused by sun exposure...Read more
Our community
- Reviews
  - - - Testimonials
        Real reviews by real people
        All the reviews on Cyspera^® Cysteamine, posted by verified users. Your reviews are very dear to us, and most important for the community. We praise each of your review and we will act upon each one individually.
        
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    - - A very happy customer
        I bought this product a couple weeks ago, and I’m very happy with the results. I’ve done chemical peels, fraxel laser among other solutions and creams… Read more “A very happy customer”
        Hillary A Miller
        Cyspera^® raises hope with no side effects
        “This cream has given me so much hope that I can’t even begin to describe it. Not only does it work, it also has zero side… Read more “Cyspera^® raises hope with no side effects”
        Minaz S.
        Even a stubborn and chronic skin condition, it works!
        Read more “Even a stubborn and chronic skin condition, it works!”
        drbdermatology
        Very happy customer
        I bought this product a couple weeks ago, and I’m very happy with the results. I’ve done chemical peels, fraxel laser among other solutions and creams… Read more “Very happy customer”
        Hillary A Miller
        Cyspera^® is safe to use indefinitely
        “I have tried many products such as hydroquinone and plant based brightening serums for my Melasma and nothing gave me a better result than @CYSPERA! It’s… Read more “Cyspera^® is safe to use indefinitely”
        Calkin Boudreaux Dermatology patient
        I’m really happy with the progress I’ve made
        Melasma: 16 week Sente Cyspera Update! I’m terrible about taking before and after pics in general but I’m really glad I did with this product. The… Read more “I’m really happy with the progress I’ve made”
        Patient - Beauty_Unplugged
        I can wear less makeup!
        “I have tried many products such as hydroquinone and plant based brightening serums for my Melasma and nothing gave me a better result than CYSPERA! It’s… Read more “I can wear less makeup!”
        calkinboudreauxdermatology
        I am so grateful and will recommend it to anyone
        I have tried so many treatments and spent a small fortune until I‘ve discovered Cyspera! Have been using it for 3 weeks and the difference is… Read more “I am so grateful and will recommend it to anyone”
        melguenthardt
        The nice thing about Cyspera, you can already see how much Cyspera has worked
        Pigmentation update.
        .
        As many of you may know, I was very kindly gifted @cyspera to test.
        I get bad melasma around my… Read more “The nice thing about Cyspera, you can already see how much Cyspera has worked”
        Talesofskincare
        Cyspera^® is actually working on my dark patches
        Finally something that works, @Cyspera is actually working on my dark patches . You have to be patient and keep going
        Amber D.
        Best product for hyperpigmentation
        Best product for hyperpigmentation! I’ve used everything made for hyperpigmentation for the last 2 years and this is the only product that has helped my dark… Read more “Best product for hyperpigmentation”
        Mika V.
        Cyspera^® is a game changer
        “Was on hydroquinone on and off for several years and although I managed to lighten my dark patches, as soon as I stopped the hydroquinone, the… Read more “Cyspera^® is a game changer”
        Hilary
        Worked on the first day of use.
        My situation might be different from most, but this cream literally saved my face ! For me, the results were immediate. I have vitiligo and after… Read more “Worked on the first day of use.”
        Amazon Customer
        WORKS AMAZINGLY WELL ON AFRICAN AMERICAN SKIN!!!!
        Okay, let’s me start with this, I purchased this item on August 15, 2017. I bought it myself, I was not given this item, nor was… Read more “WORKS AMAZINGLY WELL ON AFRICAN AMERICAN SKIN!!!!”
        Secretagentmanon
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  - - - What's happening online
        
        Be a part of Cyspera^® Community, share your story and stay tuned with our latest news
        
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  - - - News & Events
        
        Stay tuned with the lates Cyspera^® news, global events, symposiums and a lot more.
        
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- Cyspera^® Cysteamine Stories
Meet our experts
- - - Learn more with our experts
      Dr. Behrooz Kasraee, a renowned physician, passionate about skin pigmentation concerns has developed a new pigment corrector formulated with cysteamine to address the appearance of dark spots and brown patches.
      
      Learn more
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Learn more about hyperpigmentation with our experts

Doctor Jeanine Downie picture

Jeanine Downie, MD

Board-Certified Dermatologist

Image Dermatology, PC

Photo of doctor Shino Bay Aguilera

Shino Bay Aguilera, MD

Board-Certified Dermatologist

Shino Bay Cosmetic Dermatology

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Jinah Yoo, MD

Board-Certified Dermatologist

Sk:n Clinics

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Seemal Desai, MD

Board-Certified Dermatologist

Innovative Dermatology

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Dija Ayodele, MD

Board-Certified Dermatologist

Black Skin Directory, UK

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Pranav Pancoli, MD

International Board-Certified Dermatologist

Avané cosmetic dermatology clinic & medical spa

Photo of doctor Behrooz Kasraee

Behrooz Kasraee, MD

Chief Scientific Officer, SCIENTIS

Centre de Dermatologie de Cornavin & medical spa

Photo of doctor Yu-Ching Weng

Yu-Ching Weng, MD

Board-Certified Dermatologist

Taichung Veterans General Hospital

Photo of doctor Hong-Seok Kim, MD

Hong-Seok Kim, MD

Board-Certified Dermatologist

Wyne Dermatology and Laser Surgery Clinic

Dr. Behrooz Kasraee, a renowned physician, passionate about skin pigmentation concerns has developed a new pigment corrector formulated with cysteamine to address the appearance of dark spots and brown patches. With the help of global experts, we have created a series of interviews and educational materials that we are happy to offer you for free.

For physicians, you can register and get access to more educational programs

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Cyspera, an exciting breakthrough, from Dr. Ong Jin Khang

Cyspera, an exciting breakthrough, from Dr. Ong Jin Khang

Events&Conferences

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Cyspera, a color blind product for all skin type, from Dr. William Hoo

Cyspera, a color blind product for all skin type, from Dr. William Hoo

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3934 views

Cyspera® for Face and Beyond

Cyspera® for Face and Beyond

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Cyspera, a new effective & safe way to reduce appearance for hyperpigmentation

Cyspera, a new effective & safe way to reduce appearance for hyperpigmentation

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What's so special about Cyspera - explained by Dr. Yung Hsueh Huang | 聽黃勇學醫師談希思珮樂

What’s so special about Cyspera – explained by Dr. Yung Hsueh Huang | 聽黃勇學醫師談希思珮樂

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3610 views

Cyspera experience from Dr. Jason Yip

Cyspera experience from Dr. Jason Yip

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3729 views

interview-dija-ayodele

Cyspera, the novel pigment corrector for skin of color

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Cyspera, welcome on board, from Dr. Cheah Pei Lynn

Cyspera, welcome on board, from Dr. Cheah Pei Lynn

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4853 views

How Cyspera® Works On Sensitive Area

How Cyspera® Works On Sensitive Area

Events&Conferences

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Cyspera, a better option for hyperpigmentation treatment

Cyspera, a better option for hyperpigmentation treatment

Events&Conferences

2738 views

Listen to our podcast

Cyspera^® Intensive Pigment Corrector Podcast

Welcome to our Cyspera^® Podcast! Here you can join us for information on Cyspera^®, the novel pigment corrector.

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Disclaimer : Scientis products described on this website are intended to meet the EU cosmetic products regulation (EC no 1223/2009) and the FDA's definition of a cosmetic product. Scientis product is intended to be applied to the human body to cleanse, beautify, promote attractiveness, and alter appearances, and is not intended to be drug products that diagnose, treat, cure, or prevent any disease or condition. The statements on these pages have not been evaluated by EU and FDA regulators.

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